Ročník 23 Číslo 1-2
Polymorfizmus PVUII génu ESR1 a jeho asociácia s kostnou minerálnou hustotou u slovenských žien s diagnostikovanou osteoporózou
Matúš Mathia, Iveta Boroňová, Soňa Mačeková, Michaela Fecenková, Jarmila Bernasovská
Effect of PvuII polymorphism in ESR1 gene on bone mineral density in Slovak postmenopausal women with osteoporosis. The aim of this study was to investigate rs2234693 polymorphism in ESR1 gene in relation to bone mineral density in Slovak postmenopausal women with osteoporosis. The study group consisted of 97 postmenopausal osteoporotic women. Genomic DNA was extracted and purified from leukocytes by the commercial kit. Genotyping was performed using the TaqMan SNP Genotyping Assay Mix and genetic analysis was performed by real-time PCR. The basis personal, anthropometric and clinical data was obtained in cooperation with clinical osteologists. Genotype frequency of PvuII polymorphism was: CC 23.7%, CT 56.7%, and TT 19.6%. No significant difference was found in genotype frequency between fracture and non-fracture group. Lumbar spine BMD: 0.762 g/cm2, femoral neck BMD: 0.604 g/cm2 and total hip BMD: 0.690 g/cm2 in TT carries were detected. In contrast, BMD values in CC carries were: lumbar spine BMD: 0.816 g/cm2, femoral neck BMD: 0.640 g/cm2, and total hip BMD: 0.750 g/cm2. Further research, especially oriented on association analyses, is needed in Slovak population.
Antropometrické indikátory adipozity a fibrilácia predsiení u probandov z východného Slovenska
Michaela Zigová, Eva Petrejčíková, Marta Mydlárová Blaščáková, Jarmila Bernasovská, Iveta Boroňová, Ján Kmec, Martin Kmec, Michaela Gregušiak Fecenková, Jaroslava Hubcejová
Anthropometric indicators of adiposity and atrial fibrillation in probands from East Slovakia. Adiposity is a potential risk factor for most cardiovascular disorders. The aim of our study was to calculate indices of adiposity related to body weight (BMI, new BMI, BSA, and CUN-BAE) and body shape (ABSI, BF%, BRI, CI, WC, and WHtR) in 65 probands (patients and controls) from East Slovakia in the context of atrial fibrillation depending on sex. The indices of adiposity were calculated after anthropological measurements of body height, weight, waist circumference. Student’s t-test confirmed statistically significant results in comparison of ABSI (men), BF%, and CUN-BAE index (women) between atrial fibrillation patients and the control group. WHtR index values were risky in the majority of the probands (men and women from the patient’s group and control’s group). The odds ratio does not confirm a statistically significant association between atrial fibrillation and indices of adiposity in our probands but we confirmed the waist circumference as a protective factor in men with atrial fibrillation. Our results are only preliminary and we recommend investigating indices of adiposity in larger cohorts of probands.
Analýza vybraných antropometrických parametrov a parametrov zloženia tela u mladej slovenskej populácie vo veku 19 – 30 rokov
Darina Falbová, Lenka Vorobeľová, Radoslav Beňuš, Katarína Štrbová, Natália Macejková
Analysis of selected anthropometric parameters and body composition parameters in 19- to 30-year-old young Slovak population. The aim of this study was to obtain the anthropometric parameters (AP) and body composition parameters (BCP) in the examined sample of young Slovak population. The studied sample consisted of 143 men and 238 women (age range: 19–30 years). The program SPSS 20.0 was used for statistical analysis. We observed statistically significant differences between men and women in average mean values of body weight, body height, waist and hip circumference. Men had higher mean values in all selected AP than women (p<0.001). In BCP, men had significantly more fat free mass, lean body mass, skeletal muscle mass, total body water, intracellular and extracellular water, protein and mineral content, bone’s minerals than women (p<0.001). In the present study, we found that young Slovak men had significantly higher average values of active body components. In contrast, the young Slovak women had significantly higher average values of non-active body components.
Analýza daktyloskopických minúcií v oblasti tenaru/i. interdigitálneho priestoru slovenských žien
Mária Kondeková, Radoslav Beňuš, Soňa Masnicová, Petra Švábová, Kristína Kubičková
Analysis of dactyloscopic minutiae in thenar/I. interdigital palm region in Slovak women. Minutiae are the most variable elements on fingerprints and palm prints. The studied group consisted of rolled palm prints obtained from 40 Slovak women. The study aimed to evaluate the frequency of dactyloscopic minutiae in thenar/I. interdigital palm region, to determine bilateral and intersexual differences and to evaluate the most suitable minutiae type for personal identification. We used Gutiérrez et al. (2007) classification that defines 13 types of minutiae. Together, we evaluated 13,853 minutiae. The most common minutia on both hands was ridge ending (59.79%) and the least common minutiae were Y/M (0.10%) and opposite bifurcation (0.19%). We found several statistically significant intersexual differences among compared subgroup, e.g. bifurcation, bridge and Y o M. The bilateral differences were found in ridge ending and bifurcation.
Analýza vybraných polymorfizmov obezitných génov NEGR1, BDNF a MC4R v rómskej populácii východného Slovenska
Soňa Mačeková, Ľubomíra Lily Jurčišinová, Dorota Ondrušková, Stanislava Zahurančíková, Matúš Mathia, Iveta Boroňová, Jarmila Bernasovská, Dana Dojčáková
Analysis of selected polymorphisms of obesity related genes NEGR1, BDNF, and MC4R in the Roma population of eastern Slovakia. The NEGR1, BDNF and MC4R genes are candidate genes for obesity. The aim of the work was to provide pilot information on allelic and genotypic frequencies of polymorphisms of rs2815752 NEGR1 gene, rs10767664 BDNF gene and rs12970134 MC4R gene, as well as to investigate the association to obesity in the Roma minority of eastern Slovakia consisting of 456 evaluated individuals. The frequency of allele A of the NEGR1 polymorphism was 90%, allele G 10%. In the NEGR1 polymorphism, genotype AA represented 80.9%, AG 18.2% and GG 0.9%. The frequency of allele A of the BDNF polymorphism was 95% and allele T 5%. Individuals with genotype AA accounted for 92.4% of the analyzed group, with genotype AT 6.1% and TT genotype 1.5%. In the MC4R rs12970134 polymorphism, genotype GG represented 48.4%, GA 44.1% and AA 7.5%. The frequency of allele A was 29.5% and allele G 70.5%. In the case of the MC4R polymorphism, we recorded a statistically significant increase in the mean values with the presence of the risk allele in the genotype but only in the WHtR index (p=0.02). When comparing the differences in mean values of other obesity indicators between the genotypes of the monitored polymorphisms, we found no significant differences.
Analysis of anthropometric parameters and health status of Romany newborns in Chminianske Jakubovany for the period 2010–2013
Silvia Duranková, Andrej Pavúk†, Alexander Csanády, Ivana Stachoňová, Jarmila Bernasovská, Ivan Bernasovský
The aim of this study was to compare three anthropometric variables (birth weight, birth length and head circumference) of full-term Romany neonates. The studied group comprised newborns from the village of Chminianske Jakubovany. All the children examined were born in the years 2010–2013 and data came from the 37th week of pregnancy and above. A total of 256 Romanies (125 girls and 131 boys) were evaluated. We also focused on the health status of full-term Romany newborns and determined the percentage incidence of individual diseases and congenital disorders in the neonatal period in children of the Romany population. In the evaluated group 52.8% of newborns were found to have an infectious disease, 33.3% had congenital malformations and 13.8% were with other health problems. Based on the most common diseases, we were able to evaluate the possible impact of deteriorating living conditions of the Romanies.